We provide rapid development of protein therapeutics, paving the way to clinical trials.
Providing soluble and stable formulations, protein expression, purification and endotoxin removal.
Vaccines. Antibodies. Conjugates. Peptides. Enzymes. VLPs.
We believe
The ability to efficiently move biologics through the pre-clinical process gives patients the best chance of success to eliminate cancer.
HSC technology for protein formulation
HSC Technology is a cost-effective, proprietary, high-throughput system that requires minimal protein to rapidly screen hundreds of formulation conditions. The screen data generated is analyzed by an algorithm that predicts optimal additive combinations that result in soluble and physically stable formulations.
Protein stability/degradation studies
Soluble Biotech provides comprehensive stability analysis for vaccines, antibodies, conjugates, peptides, enzymes and VLPs.
Evaluation variables include all ICH requirements (i.e. pH, temperature, humidity, light, oxidizing agents and mechanical stress). We work with large and small biotech companies to design, execute, and analyze stability experiments to pass rigorous application requirements.
Stabilization kits
Soluble Biotech protein solubility kits allow rapid identification of soluble formulations. We provide four different kits to fulfill your solubility requirements. The kits are in 96- well format and provide the tools and methods to compare relative solubility across 88 common formulations (with 8 controls).
The OptiSol and OptiPharma provide mixing, filtration and collection plates for elution measurement by A280 or BCA Assay on a plate reader. The OptiSol kit includes a higher dynamic ra nge of formulat ions for more aggressive solubilization. While the OptiPharma kit includes only excipients recognized by the FDA as safe for drug development. The formulations included in the OptiPharma kit are those that Soluble Biotech has found to be most beneficial to increase solubility, based on over a decade of formulation experience for pharmaceutical companies of all sizes.
The OptiTherm and OptiResc kits include the formulations for more aggressive solubilization found in the OptiSol kits. The OptiTherm kit is a fluorescence denaturation assay of thermal stability which can be measured using a qtPCR instrument. Fluorescence profiles across a temperature profile are used to identify the relative unfolding temperatures of the protein in each formulation.
The OptiResc kit is the least quantitative of the Soluble Bioscience line of solubility kits. This kit provides an assay to identify visual clarity of previously aggregated protein solutions. While it is the least quantitative, it only requires a microscope for the visual evaluation of protein aggregate.
