HSC Technology for Protein Formulation
HSC Technology is a self-contained, automated system that conducts high-throughput, self-interaction chromatography screens, using additives and excipients commonly included in protein formulations. The data generated from these screens is analyzed by a predictive algorithm used to identify the optimal combination(s) of additives and excipients, resulting in increased solubility and physical stability of proteins.
The HSC™ Instrument, and underlying technology, has been validated over the past ten years via industry and academic collaborations. Several of our clients have seen ten-fold and hundred-fold increases in their protein’s solubility while maintaining physical stability. For biopharmaceutical clients this means faster development times and quicker progression of molecules into the clinic. For academic collaborators, this has meant further progression of biochemical & biology studies necessary to advance fundamental research in areas of unmet medical need.
“Conventional methods used to identify formulations promoting solubility and stability of proteins often cost hundreds of thousands of dollars. “HSC™ Technology accelerates the formulation process, achieving in ~12 weeks what can take a team of scientists a year or longer to achieve. Since significantly less protein is required for optimization, HSC™ is an incredibly efficient way to get past the formulation bottleneck.
HSCTM Technology was developed by Dr. Bill Wilson, former Chairman, Chemistry Department at Mississippi State University, and former NASA astronaut, Dr. Larry DeLucas, Director of the Center for Biophysical Sciences & Engineering at the University of Alabama Birmingham. Doctors Wilson and DeLucas have collaborated for the last two decades on the development of the HSC™ Technology.
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