Soluble Biotech : Services :
Formulation Development
Formulation development
Our protein formulation strategies:
We offer a tiered screening platform that can be performed using our proprietary HSC technology to solve the inherent complexities of solubility and stability.
First tier:
Single additive solubility screen
Second tier:
Comprehensive formulation screen

Single excipient solubility screen:
- Designed to quickly determine which of the FDA approved additives that will improve the solubility and stability of your protein in solution.
- Provide clients with a list of the 9 most promising additives from a set of over 40 different additives that can increase the solubility and stability of your protein formulation.
- Results can be provided in less than 6 weeks.
- Cost significantly less than it would to determine manually in your own lab
Comprehensive formulation screen:
- Provide clients with 6 most optimal formulations out of 4,000 possible combinations of buffers, excipients and concentrations.
- Quality control checks of physicochemical properties of protein in formulations are performed at different steps during the screening process.
- Results can be provided within 3-4 months.
- Cost significantly less than it would to determine manually in your own lab.

Pre-Screen
- Determine Protein Condition
- Optimize binding of protein to SIC media
- Identify minimal buffer
Initial Screen
- Screen approximately 40-60 additives
- Determine 9 most promising additives
Discovery Screen
- Screen 36 conditions from 9 additives
- Determine 8 values
- Confirm conformational stability
Formulation Screen
Delivery of formulations
- Screen approximately 40-60 additives
- Determine 9 most promising additives